BDBM342200 4-[4-[5-(3-ethoxyphenyl)-4-methyl-1H- imidazol-2-yl]-1-piperidyl]-6-(2- methoxy-4-pyridyl)-7H-pyrrolo[2,3- d]pyrimidine::US10227357, Compound P-0714::US9771369, Compound P-3034

SMILES CCOc1cccc(c1)-c1[nH]c(nc1C)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccnc(OC)c1

InChI Key InChIKey=LRANSWZLSNIOEP-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 342200   

LigandPNGBDBM342200(US9771369, Compound P-3034 | 4-[4-[5-(3-ethoxyphen...)
Affinity DataKi:  500nMAssay Description:The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2019
Entry Details
US Patent

LigandPNGBDBM342200(US9771369, Compound P-3034 | 4-[4-[5-(3-ethoxyphen...)
Affinity DataKi:  500nMAssay Description:The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetMast/stem cell growth factor receptor Kit(Human)
Plexxikon

US Patent
LigandPNGBDBM342200(US9771369, Compound P-3034 | 4-[4-[5-(3-ethoxyphen...)
Affinity DataKi:  5.50E+3nMAssay Description:Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2019
Entry Details
US Patent

TargetMast/stem cell growth factor receptor Kit(Human)
Plexxikon

US Patent
LigandPNGBDBM342200(US9771369, Compound P-3034 | 4-[4-[5-(3-ethoxyphen...)
Affinity DataKi:  1.05E+5nMAssay Description:The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent