BDBM344710 1-[1-(2-fluorophenyl)-1H-indazol-4-yl]-3-(pyridin-2-ylmethyl)imidazolidin-2-one::US9783527, Example 12

SMILES Fc1ccccc1-n1ncc2c(cccc12)N1C(=O)CN(Cc2ccccn2)C1=O

InChI Key InChIKey=XBVVGHPEJYVOSP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 344710   

LigandPNGBDBM344710(1-[1-(2-fluorophenyl)-1H-indazol-4-yl]-3-(pyridin-...)
Affinity DataIC50: 321nMAssay Description:Two days prior to the experiment, frozen HEK293 cells stably expressing recombinant human Nav1.8 (Essen, Ann Arbor, Mich.) were quickly thawed and pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2019
Entry Details
US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Abbvie

US Patent
LigandPNGBDBM344710(1-[1-(2-fluorophenyl)-1H-indazol-4-yl]-3-(pyridin-...)
Affinity DataIC50: 1.02E+3nMAssay Description:Two days prior to the experiment, frozen HEK293 cells stably expressing recombinant human Nav1.7 were quickly thawed and plated at 25,000 cells/well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2019
Entry Details
US Patent