BDBM344752 1-[1-(2-fluorophenyl)-1H-indazol-4-yl]-3-{2-[(3S)-3-fluoropiperidin-1-yl]-2-oxoethyl}imidazolidin-2-one::US9783527, Example 54

SMILES F[C@H]1CCCN(C1)C(=O)CN1CCN(C1=O)c1cccc2n(ncc12)-c1ccccc1F

InChI Key InChIKey=XCKOJHQDQVQSMM-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 344752   

TargetSodium channel protein type 9 subunit alpha(Human)
Abbvie

US Patent
LigandPNGBDBM344752(1-[1-(2-fluorophenyl)-1H-indazol-4-yl]-3-{2-[(3S)-...)
Affinity DataIC50: 1.08E+3nMAssay Description:Two days prior to the experiment, frozen HEK293 cells stably expressing recombinant human Nav1.7 were quickly thawed and plated at 25,000 cells/well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2019
Entry Details
US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Abbvie

US Patent
LigandPNGBDBM344752(1-[1-(2-fluorophenyl)-1H-indazol-4-yl]-3-{2-[(3S)-...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of recombinant human Nav1.7 expressed in HEK293F cells preincubated for 40 mins followed by DiSBAC2 substrate addition measured after 90 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
LigandPNGBDBM344752(1-[1-(2-fluorophenyl)-1H-indazol-4-yl]-3-{2-[(3S)-...)
Affinity DataIC50: 2.43E+3nMAssay Description:Two days prior to the experiment, frozen HEK293 cells stably expressing recombinant human Nav1.8 (Essen, Ann Arbor, Mich.) were quickly thawed and pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2019
Entry Details
US Patent

LigandPNGBDBM344752(1-[1-(2-fluorophenyl)-1H-indazol-4-yl]-3-{2-[(3S)-...)
Affinity DataIC50: 2.30E+4nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cells by whole cell-patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed