BDBM344786 1-{2-[(3S)-3-::1-{2-[(3S)-3-fluoropyrrolidin-1-yl]-2-oxoethyl}-3-{1-[3-(trifluoromethoxy)phenyl]-1H-indazol-4-yl}imidazolidin-2-one::US9783527, Example 88

SMILES F[C@H]1CCN(C1)C(=O)CN1CCN(C1=O)c1cccc2n(ncc12)-c1cccc(OC(F)(F)F)c1

InChI Key InChIKey=UBPSGFRDPVRFFF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 344786   

TargetSodium channel protein type 9 subunit alpha(Human)
Abbvie

US Patent
LigandPNGBDBM344786(1-{2-[(3S)-3-fluoropyrrolidin-1-yl]-2-oxoethyl}-3-...)
Affinity DataIC50: 351nMAssay Description:Two days prior to the experiment, frozen HEK293 cells stably expressing recombinant human Nav1.7 were quickly thawed and plated at 25,000 cells/well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2019
Entry Details
US Patent

LigandPNGBDBM344786(1-{2-[(3S)-3-fluoropyrrolidin-1-yl]-2-oxoethyl}-3-...)
Affinity DataIC50: 1.37E+3nMAssay Description:Two days prior to the experiment, frozen HEK293 cells stably expressing recombinant human Nav1.8 (Essen, Ann Arbor, Mich.) were quickly thawed and pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2019
Entry Details
US Patent