BDBM345033 N-[(1R,2R)-2-::N-[(1R,2R)-2-(benzyloxy)cyclopentyl]-2-{3-[1-(2-fluorophenyl)-1H-indazol-4-yl]-2-oxoimidazolidin-1-yl}acetamide::US9783527, Example 335

SMILES Fc1ccccc1-n1ncc2c(cccc12)N1CCN(CC(=O)N[C@@H]2CCC[C@H]2OCc2ccccc2)C1=O

InChI Key InChIKey=SNXQZKMRWYHBMD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 345033   

LigandPNGBDBM345033(N-[(1R,2R)-2-(benzyloxy)cyclopentyl]-2-{3-[1-(2-fl...)
Affinity DataIC50: 501nMAssay Description:Two days prior to the experiment, frozen HEK293 cells stably expressing recombinant human Nav1.8 (Essen, Ann Arbor, Mich.) were quickly thawed and pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2019
Entry Details
US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Abbvie

US Patent
LigandPNGBDBM345033(N-[(1R,2R)-2-(benzyloxy)cyclopentyl]-2-{3-[1-(2-fl...)
Affinity DataIC50: 1.11E+3nMAssay Description:Two days prior to the experiment, frozen HEK293 cells stably expressing recombinant human Nav1.7 were quickly thawed and plated at 25,000 cells/well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2019
Entry Details
US Patent