BDBM345146 1-(2,3-Dichloro-4-((2-((3-methoxy-5-(2-morpholinoethoxy)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)-3-(1-(p-tolyl)-3-(trimethylsilyl)-1H-pyrazol-5-yl)urea::US9783556, Example 18

SMILES COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)[Si](C)(C)C)c(Cl)c3Cl)n2)cc(OCCN2CCOCC2)c1

InChI Key InChIKey=QVZIZZNXCLSQQR-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 345146   

Target5-hydroxytryptamine receptor 2A(Human)
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LigandPNGBDBM345146(1-(2,3-Dichloro-4-((2-((3-methoxy-5-(2-morpholinoe...)
Affinity DataIC50: 1.00E+3nMAssay Description:The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair
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Date in BDB:
8/19/2019
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TargetProto-oncogene tyrosine-protein kinase Src(Human)
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LigandPNGBDBM345146(1-(2,3-Dichloro-4-((2-((3-methoxy-5-(2-morpholinoe...)
Affinity DataIC50: 41nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair
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Date in BDB:
8/19/2019
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TargetTyrosine-protein kinase SYK(Human)
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LigandPNGBDBM345146(1-(2,3-Dichloro-4-((2-((3-methoxy-5-(2-morpholinoe...)
Affinity DataIC50: 59nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2019
Entry Details
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TargetGlycogen synthase kinase-3 alpha(Human)
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LigandPNGBDBM345146(1-(2,3-Dichloro-4-((2-((3-methoxy-5-(2-morpholinoe...)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2019
Entry Details
Go to US Patent