BDBM345150 3-Ethynyl-N-(2-morpholinoethyl)-5-((4-((4-(3-(1-(p-tolyl)-3-(trimethylsilyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)benzamide::US9783556, Example 22

SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ncnc(Nc3cc(cc(c3)C(=O)NCCN3CCOCC3)C#C)n2)c2ccccc12)[Si](C)(C)C

InChI Key InChIKey=BSTCRUFJLBKYMG-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 345150   

Target5-hydroxytryptamine receptor 2A(Human)
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US Patent
LigandPNGBDBM345150(3-Ethynyl-N-(2-morpholinoethyl)-5-((4-((4-(3-(1-(p...)
Affinity DataIC50: 108nMAssay Description:The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair
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Date in BDB:
8/19/2019
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TargetProto-oncogene tyrosine-protein kinase Src(Human)
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LigandPNGBDBM345150(3-Ethynyl-N-(2-morpholinoethyl)-5-((4-((4-(3-(1-(p...)
Affinity DataIC50: 25nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair
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Date in BDB:
8/19/2019
Entry Details
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TargetTyrosine-protein kinase SYK(Human)
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US Patent
LigandPNGBDBM345150(3-Ethynyl-N-(2-morpholinoethyl)-5-((4-((4-(3-(1-(p...)
Affinity DataIC50: 65nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2019
Entry Details
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TargetGlycogen synthase kinase-3 alpha(Human)
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US Patent
LigandPNGBDBM345150(3-Ethynyl-N-(2-morpholinoethyl)-5-((4-((4-(3-(1-(p...)
Affinity DataIC50: 416nMAssay Description:The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2019
Entry Details
Go to US Patent