BDBM345521 N-(2-(2,4-difluorophenoxy)-6-(1,5- dimethyl-6-oxo-1,6-dihydropyridin- 3-yl)pyrimidin-4- yl)cyclopentanesulfonamide::US10202360, Example 66

SMILES Cc1cc(cn(C)c1=O)-c1cc(NS(=O)(=O)C2CCCC2)nc(Oc2ccc(F)cc2F)n1

InChI Key InChIKey=QGHCKFACSVCALW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 345521   

TargetCREB-binding protein(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM345521(US10202360, Example 66 | N-(2-(2,4-difluorophenoxy...)
Affinity DataIC50: 500nMAssay Description:Determination of the IC50 for the CREBBP inhibitors disclosed herein was performed as follows: CREBBP was cloned and expressed in E. Coli as His-tag ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2019
Entry Details
US Patent

TargetCREB-binding protein(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM345521(US10202360, Example 66 | N-(2-(2,4-difluorophenoxy...)
Affinity DataIC50: 500nMAssay Description:Determination of the IC50 for the CREBBP inhibitors disclosed herein was performed as follows: CREBBP was cloned and expressed in E. Coli as His-tag ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2019
Entry Details
US Patent

TargetBromodomain-containing protein 4 [42-168](Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM345521(US10202360, Example 66 | N-(2-(2,4-difluorophenoxy...)
Affinity DataIC50: 2.75E+3nMAssay Description:Inhibition of BRD4 was determined as previously described in U.S. Pat. No. 9,034,900.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2019
Entry Details
US Patent