BDBM347641 2-Methyl-6-((4-(1-methyl-4-(pyridin-4-yl)-1H-pyrazol-3-yl)phenyl)ethynyl)pyridine::US9790203, Example 9

SMILES Cc1cccc(n1)C#Cc1ccc(cc1)-c1nn(C)cc1-c1ccncc1

InChI Key InChIKey=HUCMITQPBMEQLZ-UHFFFAOYSA-N

Data  1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 347641   

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Abbvie

US Patent

LigandBDBM347641(2-Methyl-6-((4-(1-methyl-4-(pyridin-4-yl)-1H-pyraz...)Copy SMILESCopy InChI

Affinity DataIC50: 100nMAssay Description:The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
9/9/2019
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL