BDBM347664 1-(3-(2-Methylbut-3-yn-2-yl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-((3-(2-morpholinoethoxy)phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US9790209, Example 5

SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cccc(OCCN4CCOCC4)c3)n2)c2ccccc12)C(C)(C)C#C

InChI Key InChIKey=KGPGREGIGZVOML-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 347664   

TargetGlycogen synthase kinase-3 alpha(Human)
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US Patent
LigandPNGBDBM347664(1-(3-(2-Methylbut-3-yn-2-yl)-1-(p-tolyl)-1H-pyrazo...)
Affinity DataIC50: 602nMAssay Description:The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...More data for this Ligand-Target Pair
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Date in BDB:
9/9/2019
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