BDBM347669 1-(4-((2-((6-(2-(Dimethylamino)ethoxy)pyridin-2-yl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)-3-(3-(2-methylbut-3-yn-2-yl)-1-(p-tolyl)-1H-pyrazol-5-yl)urea::US9790209, Example 10

SMILES CN(C)CCOc1cccc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C#C)c4ccccc34)n2)n1

InChI Key InChIKey=DUSXIPBDGRZEQW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 347669   

Target5-hydroxytryptamine receptor 2A(Human)
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US Patent
LigandPNGBDBM347669(1-(4-((2-((6-(2-(Dimethylamino)ethoxy)pyridin-2-yl...)
Affinity DataIC50: 46nMAssay Description:The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), are evaluated indirectly by determining the leve...More data for this Ligand-Target Pair
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Date in BDB:
9/9/2019
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TargetGlycogen synthase kinase-3 alpha(Human)
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US Patent
LigandPNGBDBM347669(1-(4-((2-((6-(2-(Dimethylamino)ethoxy)pyridin-2-yl...)
Affinity DataIC50: 1.76E+3nMAssay Description:The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2019
Entry Details
Go to US Patent