BDBM349253 (4R)-4-methyl-6-[1-methyl-6-(1-methylpyrazol-4-yl)indol-2-yl]-1,3,4,5-tetrahydro-1,5-benzodiazepin-2-one::US10206931, Example 60

SMILES C[C@@H]1CC(=O)Nc2cccc(-c3cc4ccc(cc4n3C)-c3cnn(C)c3)c2N1

InChI Key InChIKey=CTDMZYNQXMPGEJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 349253   

TargetCREB-binding protein(Human)
Genentech

US Patent
LigandPNGBDBM349253((4R)-4-methyl-6-[1-methyl-6-(1-methylpyrazol-4-yl)...)
Affinity DataIC50: 40nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetBromodomain-containing protein 4 [42-168](Human)
Genentech

US Patent
LigandPNGBDBM349253((4R)-4-methyl-6-[1-methyl-6-(1-methylpyrazol-4-yl)...)
Affinity DataIC50: 637nMAssay Description:His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent