BDBM349273 (2R)-6-chloro-9-(3-cyclopropyl-1-methyl-indazol-5-yl)-2-methyl-1,2,3,5-tetrahydro-1,5-benzodiazepin-4-one::US10206931, Example 80

SMILES CNc1ccc(cc1C(=N)C1CC1)-c1ccc(Cl)c2NC(=O)C[C@@H](C)Nc12

InChI Key InChIKey=ULXZYSGYJBTMNU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 349273   

TargetCREB-binding protein(Human)
Genentech

US Patent
LigandPNGBDBM349273((2R)-6-chloro-9-(3-cyclopropyl-1-methyl-indazol-5-...)
Affinity DataIC50: 30nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [42-168](Human)
Genentech

US Patent
LigandPNGBDBM349273((2R)-6-chloro-9-(3-cyclopropyl-1-methyl-indazol-5-...)
Affinity DataIC50: 1.69E+3nMAssay Description:His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent