BDBM349276 (4R)-6-(3-cyclopropyl-1-methyl-indazol-5-yl)-4-methyl-2-oxo-1,3,4,5-tetrahydro-1,5-benzodiazepine-9-carbonitrile::US10206931, Example 83

SMILES CNc1ccc(cc1C(=N)C1CC1)-c1ccc(C#N)c2NC(=O)C[C@@H](C)Nc12

InChI Key InChIKey=CVAPCCYFIOFWPD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 349276   

TargetCREB-binding protein(Human)
Genentech

US Patent
LigandPNGBDBM349276((4R)-6-(3-cyclopropyl-1-methyl-indazol-5-yl)-4-met...)
Affinity DataIC50: 82nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
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TargetBromodomain-containing protein 4 [42-168](Human)
Genentech

US Patent
LigandPNGBDBM349276((4R)-6-(3-cyclopropyl-1-methyl-indazol-5-yl)-4-met...)
Affinity DataIC50: 4.91E+3nMAssay Description:His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent