BDBM349277 (2R)-9-(3-cyclopropyl-1-methyl-indazol-5-yl)-6-fluoro-2-methyl-1,2,35-tetrahydro-1,5-benzodiazepin-4-one::US10206931, Example 84

SMILES CNc1ccc(cc1C(=N)C1CC1)-c1ccc(F)c2NC(=O)C[C@@H](C)Nc12

InChI Key InChIKey=XVNAECYVLQPWDR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 349277   

TargetCREB-binding protein(Human)
Genentech

US Patent
LigandPNGBDBM349277((2R)-9-(3-cyclopropyl-1-methyl-indazol-5-yl)-6-flu...)
Affinity DataIC50: 26nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetBromodomain-containing protein 4 [42-168](Human)
Genentech

US Patent
LigandPNGBDBM349277((2R)-9-(3-cyclopropyl-1-methyl-indazol-5-yl)-6-flu...)
Affinity DataIC50: 1.48E+3nMAssay Description:His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent