BDBM349287 (4R)-4-methyl-6-[1-methyl-3-(1-methylpyrazol-4-yl)indazol-5-yl]-1,3,4,5-tetrahydropyrido[3,4-b][1,4]diazepin-2-one::US10206931, Example 94

SMILES CN\C=C(/C=N)C(=N)c1cc(ccc1NC)-c1nccc2NC(=O)C[C@@H](C)Nc12

InChI Key InChIKey=NDKKNTSLBVWOCV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 349287   

TargetCREB-binding protein(Human)
Genentech

US Patent
LigandPNGBDBM349287((4R)-4-methyl-6-[1-methyl-3-(1-methylpyrazol-4-yl)...)
Affinity DataIC50: 54nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetBromodomain-containing protein 4 [42-168](Human)
Genentech

US Patent
LigandPNGBDBM349287((4R)-4-methyl-6-[1-methyl-3-(1-methylpyrazol-4-yl)...)
Affinity DataIC50: 7.74E+3nMAssay Description:His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent