BDBM349364 (4R)-6-(1-tert-butylpyrazol-4-::US10206931, Example 172

SMILES C[C@@H]1CC(=O)Nc2cccc(-c3cnn(c3)C(C)(C)C)c2N1

InChI Key InChIKey=HPSNXSAYALRMQW-UHFFFAOYSA-N

Data  4 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 349364   

TargetCREB-binding protein(Human)
Genentech

US Patent
LigandPNGBDBM349364((4R)-6-(1-tert-butylpyrazol-4- | US10206931, Examp...)
Affinity DataIC50: 456nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [42-168](Human)
Genentech

US Patent
LigandPNGBDBM349364((4R)-6-(1-tert-butylpyrazol-4- | US10206931, Examp...)
Affinity DataIC50: 2.02E+4nMAssay Description:His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent

TargetCREB-binding protein/Histone acetyltransferase p300(Human)
Jilin University

Curated by ChEMBL
LigandPNGBDBM349364((4R)-6-(1-tert-butylpyrazol-4- | US10206931, Examp...)
Affinity DataIC50: 470nMAssay Description:Inhibition of human His-FLAG tagged CBP/EP300 (1082 to 1197 residues) using H4-TetraAc-biotin peptide as substrate after 90 mins by AlphaLISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
Genentech

US Patent
LigandPNGBDBM349364((4R)-6-(1-tert-butylpyrazol-4- | US10206931, Examp...)
Affinity DataIC50: 470nMAssay Description:Inhibition of His-FLAG-tagged CBP ( 1082 to 1197 residues) (unknown origin) using H4-tetraAc-biotin as substrate incubated for 20 mins by AlphaLISA a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
Genentech

US Patent
LigandPNGBDBM349364((4R)-6-(1-tert-butylpyrazol-4- | US10206931, Examp...)
Affinity DataEC50:  2.10E+3nMAssay Description:Inhibition of NanoLuc tagged CBP bromodomain (unknown origin) expressed in HEK293 cells harboring Halo-tagged histone H3.3 by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed