BDBM349482 (R)-4-methyl-6-(6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl)-4,5-dihydro-1H-benzo[b][1,4]diazepin-2(3H)-one::US10206931, Example 290

SMILES CN\C=C(/C=N)c1ccc2N(CCCc2c1)c1cccc2NC(=O)C[C@@H](C)Nc12

InChI Key InChIKey=FMBMAQIQOYEWJY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 349482   

TargetCREB-binding protein(Human)
Genentech

US Patent
LigandPNGBDBM349482((R)-4-methyl-6-(6-(1-methyl-1H-pyrazol-4-yl)-3,4-d...)
Affinity DataIC50: 14nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetBromodomain-containing protein 4 [42-168](Human)
Genentech

US Patent
LigandPNGBDBM349482((R)-4-methyl-6-(6-(1-methyl-1H-pyrazol-4-yl)-3,4-d...)
Affinity DataIC50: 3.24E+3nMAssay Description:His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent