BDBM349488 US10206931, Example 296::methylpyrazol-4-

SMILES CN\C=C(/C=N)c1cccc(Nc2cccc3NC(=O)C[C@@H](C)Nc23)c1

InChI Key InChIKey=CCKZXLBSTAINNP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 349488   

TargetCREB-binding protein(Human)
Genentech

US Patent
LigandPNGBDBM349488(methylpyrazol-4- | US10206931, Example 296)
Affinity DataIC50: 9nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
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TargetBromodomain-containing protein 4 [42-168](Human)
Genentech

US Patent
LigandPNGBDBM349488(methylpyrazol-4- | US10206931, Example 296)
Affinity DataIC50: 4.71E+3nMAssay Description:His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent