BDBM349499 (R,R)-6-[7-(difluoromethyl)-4-methyl-6-(l-methylpyrazol-4-yl)-3,4-dihydro-2H-quinolin-1-yl]-4-methyl-1,3,4,5-tetrahydro-1,5-benzodiazepin-2-one & (R,S)-6-[7-(difluoromethyl)-4-methyl-6-(1-methylpyrazol-4-yl)-3,4-dihydro-2H-quinolin-1-yl]-4-methyl-1,3,4,5-tetrahydro-1,5-benzodiazepin-2-one::US10206931, Example 307

SMILES CN\C=C(/C=N)c1cc2[C@H](C)CCN(c2cc1C(F)F)c1cccc2NC(=O)C[C@@H](C)Nc12

InChI Key InChIKey=TVFZSBFYTFXALS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 349499   

TargetCREB-binding protein(Human)
Genentech

US Patent
LigandPNGBDBM349499((R,R)-6-[7-(difluoromethyl)-4-methyl-6-(l-methylpy...)
Affinity DataIC50: 19nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
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TargetBromodomain-containing protein 4 [42-168](Human)
Genentech

US Patent
LigandPNGBDBM349499((R,R)-6-[7-(difluoromethyl)-4-methyl-6-(l-methylpy...)
Affinity DataIC50: 1.16E+4nMAssay Description:His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent