BDBM349630 US10208011, Compound RAD-::US10981887, Compound RAD-

SMILES CCNCCc1ccc(cc1)CN(CC)c2cc(ccc2[C@@H]3CCc4cc(ccc4C3)O)OC

InChI Key InChIKey=SIFNOOUKXBRGGB-UHFFFAOYSA-N

Data  8 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 349630   

TargetG-protein coupled estrogen receptor 1(Human)
G1 Therapeutics

US Patent
LigandPNGBDBM349630(US10208011, Compound RAD- | US10981887, Compound R...)
Affinity DataIC50: 1.00E+3nMAssay Description:A screening strategy was implemented utilizing an In-Cell Western assay to measure their ability to degrade the estrogen receptor in vitro. MCF7 cell...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent

TargetG-protein coupled estrogen receptor 1(Human)
G1 Therapeutics

US Patent
LigandPNGBDBM349630(US10208011, Compound RAD- | US10981887, Compound R...)
Affinity DataIC50: 1.00E+3nMAssay Description:All reagents used in this assay was supplied in the Human ERα Reporter Assay by Indigo Biosciences # IB00401. In an effort to screen selective e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
G1 Therapeutics

US Patent
LigandPNGBDBM349630(US10208011, Compound RAD- | US10981887, Compound R...)
Affinity DataIC50: 1.00E+3nMAssay Description:A screening strategy was implemented utilizing an In-Cell Western assay to measure their ability to degrade the estrogen receptor in vitro. MCF7 cell...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
G1 Therapeutics

US Patent
LigandPNGBDBM349630(US10208011, Compound RAD- | US10981887, Compound R...)
Affinity DataIC50: 1.00E+3nMAssay Description:All reagents used in this assay was supplied in the Human ERα Reporter Assay by Indigo Biosciences #IB00401. In an effort to screen selective es...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
G1 Therapeutics

US Patent
LigandPNGBDBM349630(US10208011, Compound RAD- | US10981887, Compound R...)
Affinity DataIC50: 48nMAssay Description:Inhibition of ERalpha (unknown origin) incubated for 4 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetEstrogen receptor beta(Human)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM349630(US10208011, Compound RAD- | US10981887, Compound R...)
Affinity DataIC50: 870nMAssay Description:Inhibition of ERbeta (unknown origin) incubated for 4 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetEstrogen receptor(Human)
G1 Therapeutics

US Patent
LigandPNGBDBM349630(US10208011, Compound RAD- | US10981887, Compound R...)
Affinity DataIC50: 48nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetEstrogen receptor beta(Human)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM349630(US10208011, Compound RAD- | US10981887, Compound R...)
Affinity DataIC50: 870nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed