BDBM349911 (S)-5-(4-(3-(4- chlorobenzyl)morpholino) piperidin-1-yl)-4H-1,2,4- triazol-3-amine::US10208020, Example 1::US9944624, Ex. 1

SMILES NC4=NNC(N3CCC(N1CCOC[C@@H]1Cc2ccc(Cl)cc2)CC3)N4

InChI Key InChIKey=KCRJQPQOGNORFX-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 349911   

TargetChitotriosidase-1(Human)
Oncoarendi Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 349911BDBM349911((S)-5-(4-(3-(4- chlorobenzyl)morpholino) piperidin...)
Affinity DataIC50: 100nMAssay Description:An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2020
Entry Details
US Patent

TargetAcidic mammalian chitinase(Human)
Oncoarendi Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 349911BDBM349911((S)-5-(4-(3-(4- chlorobenzyl)morpholino) piperidin...)
Affinity DataIC50: 100nMAssay Description:An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetAcidic mammalian chitinase(Human)
Oncoarendi Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 349911BDBM349911((S)-5-(4-(3-(4- chlorobenzyl)morpholino) piperidin...)
Affinity DataIC50: 100nMAssay Description:An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2020
Entry Details
US Patent

TargetChitotriosidase-1(Human)
Oncoarendi Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 349911BDBM349911((S)-5-(4-(3-(4- chlorobenzyl)morpholino) piperidin...)
Affinity DataIC50: 100nMAssay Description:An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent