BDBM350310 8-((R)-2-hydroxy-2-((R)-5-methyl-5H-tetrazolo[5,1-a]isoindol-7-yl)ethyl)-2-(4-methyl-5-oxo-2,5-dihydrofuran-3-yl)-2,8-diazaspiro[4.5]decan-1-one::US10208064, Example 27C

SMILES C[C@@H]1c2cc(ccc2-c2nnnn12)[C@@H](O)CN1CCC2(CCN(C3=C(C)C(=O)OC3)C2=O)CC1

InChI Key InChIKey=ZYGITUJDIQCVRW-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 350310   

TargetATP-sensitive inward rectifier potassium channel 1(Human)
Wuxi Apptec (Shanghai)

US Patent
LigandPNGBDBM350310(8-((R)-2-hydroxy-2-((R)-5-methyl-5H-tetrazolo[5,1-...)
Affinity DataIC50: 36nMAssay Description:A Thallium Flux Assay was performed on the compounds of the Examples. This assay has been described previously; see, e.g., PCT Published Application ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
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