BDBM352484 US10745364, Example 2C::US9809561, 2C::[(R)-4-(3-chloro-benzenesulfonyl)-2- hydroxymethyl-3,4-dihydro-2H- benzo[1,4]oxazin-6-yl]-carbamic acid tert-butyl ester

SMILES CC(C)(C)OC(=O)Nc1ccc2O[C@@H](CO)CN(c2c1)S(=O)(=O)c1cccc(Cl)c1

InChI Key InChIKey=WMYHWVQAEMHQEQ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 352484   

TargetNuclear receptor ROR-gamma(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM352484([(R)-4-(3-chloro-benzenesulfonyl)-2- hydroxymethyl...)
Affinity DataIC50: 4.57nMAssay Description:The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2019
Entry Details
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TargetNuclear receptor ROR-gamma(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM352484([(R)-4-(3-chloro-benzenesulfonyl)-2- hydroxymethyl...)
Affinity DataIC50: 4.57nMAssay Description:HIS-tagged RORγ-LBD protein was recombinantly expressed in Escherichia coli. The RORγ-LBD protein was purified by Ni2+-affinity resin. Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
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TargetNuclear receptor ROR-gamma(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM352484([(R)-4-(3-chloro-benzenesulfonyl)-2- hydroxymethyl...)
Affinity DataIC50: 4.57nMAssay Description:To identify novel antagonists of RORgammaT, an assay was developed which employs the interaction of RORgammaT with its co-activator peptide SRC1_2. T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2021
Entry Details
Go to US Patent