BDBM352785 (S)-tert-butyl (2-((2H-1,2,3-triazol-2- yl)methyl)-4-((3- (trifluoromethyl)phenyl)sulfonyl)-3,4- dihydro-2H-benzo[b][1,4]oxazin-6- yl)carbamate::US10745364, Example 63F::US9809561, 63F

SMILES CC(C)(C)OC(=O)Nc1ccc2O[C@@H](Cn3nccn3)CN(c2c1)S(=O)(=O)c1cccc(c1)C(F)(F)F

InChI Key InChIKey=BTXYHMUNXNUQSY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 352785   

TargetNuclear receptor ROR-gamma(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM352785(US9809561, 63F | (S)-tert-butyl (2-((2H-1,2,3-tria...)
Affinity DataIC50: 2.78nMAssay Description:The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2019
Entry Details
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TargetNuclear receptor ROR-gamma(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM352785(US9809561, 63F | (S)-tert-butyl (2-((2H-1,2,3-tria...)
Affinity DataIC50: 2.78nMAssay Description:HIS-tagged RORγ-LBD protein was recombinantly expressed in Escherichia coli. The RORγ-LBD protein was purified by Ni2+-affinity resin. Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
Go to US Patent

TargetNuclear receptor ROR-gamma(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM352785(US9809561, 63F | (S)-tert-butyl (2-((2H-1,2,3-tria...)
Affinity DataIC50: 2.78nMAssay Description:To identify novel antagonists of RORgammaT, an assay was developed which employs the interaction of RORgammaT with its co-activator peptide SRC1_2. T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2021
Entry Details
Go to US Patent