BDBM354186 (R)-5-(2-(5-fluoro-2- methoxypyridin-3-yl)pyrrolidin-1- yl)-N-(3- hydroxypropyl)pyrazolo[l,5- a]pyrimidine-3-carboxamide::US9796724, Example 148

SMILES COc1ncc(F)cc1C1CCCN1c1ccn2ncc(C(=O)NCCCO)c2n1

InChI Key InChIKey=VTUVGNKQBUVKIW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 354186   

TargetHigh affinity nerve growth factor receptor(Human)
Array Biopharma

US Patent
LigandPNGBDBM354186((R)-5-(2-(5-fluoro-2- methoxypyridin-3-yl)pyrrolid...)
Affinity DataIC50: 1.10nMAssay Description:Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2019
Entry Details
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TargetTyrosine-protein kinase JAK2 [808-1132](Human)
Array Biopharma

US Patent
LigandPNGBDBM354186((R)-5-(2-(5-fluoro-2- methoxypyridin-3-yl)pyrrolid...)
Affinity DataIC50: 1.00E+3nMAssay Description:Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2019
Entry Details
Go to US Patent