BDBM355374 N-[(1R)-2,2-dimethyl-1-{4- [(trifluoromethyl)sulfanyl]phenyl} propyl]-2-(4-methoxybenzyl)-6-oxo- 1,6-dihydropyrimidine-4- carboxamide::US9815796, Example 465

SMILES COc1ccc(Cc2nc(cc(=O)[nH]2)C(=O)N[C@@H](c2ccc(SC(F)(F)F)cc2)C(C)(C)C)cc1

InChI Key InChIKey=SHSHBEHPKYSHLS-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 355374   

TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM355374(US9815796, Example 465 | N-[(1R)-2,2-dimethyl-1-{4...)
Affinity DataKi:  0.620nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details
US Patent

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM355374(US9815796, Example 465 | N-[(1R)-2,2-dimethyl-1-{4...)
Affinity DataKi:  0.620nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details
US Patent