BDBM355683 1-{2-[(1R,3S,5R)-3-((1R,2R)-2- Fluoro-2-phenyl- cyclopropylcarbamoyl)-2-aza- bicyclo[3.1.0]hex-2-yl]-2-oxo-ethyl}- 5-methyl-1H-pyrazolo[3,4- c]pyridine-3-carboxylic acid amide::US9815819, 48

SMILES Cc1cc2c(nn(CC(=O)N3[C@@H]4C[C@@H]4C[C@H]3C(=O)N[C@@H]3C[C@@]3(F)c3ccccc3)c2cn1)C(N)=O

InChI Key InChIKey=QWLHKEAOEMFIQW-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 355683   

TargetComplement factor D(Human)
Novartis

US Patent
LigandPNGBDBM355683(US9815819, 48 | 1-{2-[(1R,3S,5R)-3-((1R,2R)-2- Flu...)
Affinity DataIC50: 30nMAssay Description:Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details
US Patent