BDBM355713 1-{2-Oxo-2-[(1R,3S,5R)-3-(3- phenyl-cyclohexylcarbamoyl)-2- aza-bicyclo[3.1.0]hex-2-yl]-ethyl}- 1H-indazole-3-carboxylic acid amideDia 1::US9815819, 78::US9815819, 79::US9815819, 80::US9815819, 81

SMILES NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NC2CCCC(C2)c2ccccc2)c2ccccc12

InChI Key InChIKey=QHZNSUVGWSMLDQ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 355713   

TargetComplement factor D(Human)
Novartis

US Patent
LigandPNGBDBM355713(US9815819, 78 | 1-{2-Oxo-2-[(1R,3S,5R)-3-(3- pheny...)
Affinity DataIC50: 114nMAssay Description:Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details
US Patent

TargetComplement factor D(Human)
Novartis

US Patent
LigandPNGBDBM355713(US9815819, 78 | 1-{2-Oxo-2-[(1R,3S,5R)-3-(3- pheny...)
Affinity DataIC50: 475nMAssay Description:Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details
US Patent

TargetComplement factor D(Human)
Novartis

US Patent
LigandPNGBDBM355713(US9815819, 78 | 1-{2-Oxo-2-[(1R,3S,5R)-3-(3- pheny...)
Affinity DataIC50: 2.00E+3nMAssay Description:Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details
US Patent

TargetComplement factor D(Human)
Novartis

US Patent
LigandPNGBDBM355713(US9815819, 78 | 1-{2-Oxo-2-[(1R,3S,5R)-3-(3- pheny...)
Affinity DataIC50: 5.65E+3nMAssay Description:Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details
US Patent