BDBM35572 JMC527081 Compound 5f::pyrazolo pyrimidine, 1

SMILES Oc1cccc(c1)-c1nc(N2CCOCC2)c2cnn(C3CCN(Cc4cccnc4)CC3)c2n1

InChI Key InChIKey=VAOSXQKPRPFALK-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 35572   

TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM35572(JMC527081 Compound 5f | pyrazolo pyrimidine, 1)
Affinity DataIC50: 9.60nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM35572(JMC527081 Compound 5f | pyrazolo pyrimidine, 1)
Affinity DataIC50: 10nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2009
Entry Details Article
PubMed
LigandPNGBDBM35572(JMC527081 Compound 5f | pyrazolo pyrimidine, 1)
Affinity DataIC50: 47nMT: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2009
Entry Details Article
PubMed
LigandPNGBDBM35572(JMC527081 Compound 5f | pyrazolo pyrimidine, 1)
Affinity DataIC50: 47nMT: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2009
Entry Details Article
PubMed