BDBM35588 pyrazolo pyrimidine, 20

SMILES COC(=O)N1CCC(CC1)n1ncc2c(nc(nc12)-c1ccc(NC(=O)OCCO)cc1)N1CCOCC1

InChI Key InChIKey=SLESJLZOADSRKF-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 35588   

TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandBDBM35588(pyrazolo pyrimidine, 20)Copy SMILESCopy InChI

Affinity DataIC50: 1nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/14/2009
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Wyeth Research

LigandBDBM35588(pyrazolo pyrimidine, 20)Copy SMILESCopy InChI

Affinity DataIC50: 681nMT: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/14/2009
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL