BDBM356161 2-fluoro-5-(1-methyl-1H- pyrazol-3-yl)-N-(5-oxo-2- phenyl-6,7-dihydro-5H- pyrrolo[3,4-b]pyridin-3-yl)-4- (trifluoromethyl)benzamide::US9815846, Compound 161

SMILES Cn1ccc(n1)-c1cc(C(=O)Nc2cc3C(=O)NCc3nc2-c2ccccc2)c(F)cc1C(F)(F)F

InChI Key InChIKey=WQRLTGYCXGUULM-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 356161   

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM356161(US9815846, Compound 161 | 2-fluoro-5-(1-methyl-1H-...)
Affinity DataIC50: 0.380nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2019
Entry Details
US Patent