BDBM356570 N-Methyl-N-(tetrahydro-2H-pyran-4-yl)-2-(4-{3-[3-({[(2,2,2-trifluoroethyl)amino]carbonyl}amino)phenyl]imidazo[1,2-b]pyridazin-7-yl}-1H-pyrazol-1-yl)propanamide::US10213427, Example 59::US10813930, Ex. No. 59

SMILES CC(N\C=C(/C=N)c1cnn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1)C(=O)N(C)C1CCOCC1

InChI Key InChIKey=UPVPMRSMOCOCAF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 356570   

TargetFibroblast growth factor receptor 3(Human)
Incyte

US Patent
LigandPNGBDBM356570(N-Methyl-N-(tetrahydro-2H-pyran-4-yl)-2-(4-{3-[3-(...)
Affinity DataIC50: 10nMAssay Description:The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent

TargetFibroblast growth factor receptor 3(Human)
Incyte

US Patent
LigandPNGBDBM356570(N-Methyl-N-(tetrahydro-2H-pyran-4-yl)-2-(4-{3-[3-(...)
Affinity DataIC50: 10nMAssay Description:FGFR3 Enzymatic Assay The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent