BDBM35673 5H-1-benzazepin-5-ylidene acetamide, 1a::BMC169524 Compound 10a

SMILES Cc1ccn(n1)-c1ccc(C(=O)N2CCC(F)(F)\C(=C/C(=O)NCc3ccccn3)c3ccccc23)c(Cl)c1

InChI Key InChIKey=GRCPGLCEGKJUFI-UHFFFAOYSA-N

Data  4 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 35673   

TargetVasopressin V2 receptor(Human)
Astellas Pharma

LigandPNGBDBM35673(BMC169524 Compound 10a | 5H-1-benzazepin-5-ylidene...)
Affinity DataKi:  4.80nM ΔG°:  -11.3kcal/mole EC50:  1.80nMpH: 7.4 T: 2°CAssay Description:The affinities of test compounds for human V2 receptor were evaluated by the radioligand binding study using membrane fractions isolated from CHO cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2009
Entry Details Article
PubMed
TargetVasopressin V2 receptor(Human)
Astellas Pharma

LigandPNGBDBM35673(BMC169524 Compound 10a | 5H-1-benzazepin-5-ylidene...)
Affinity DataKi:  4.80nM ΔG°:  -11.3kcal/molepH: 7.4 T: 2°CAssay Description:The affinities of test compounds for human V2 receptor were evaluated by the radioligand binding study using membrane fractions isolated from CHO cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2009
Entry Details Article
PubMed
TargetVasopressin V2 receptor(Rat)
Astellas Pharma

LigandPNGBDBM35673(BMC169524 Compound 10a | 5H-1-benzazepin-5-ylidene...)
Affinity DataKi:  19nM ΔG°:  -10.5kcal/molepH: 7.4 T: 2°CAssay Description:The affinities of test compounds for human V2 receptor were evaluated by the radioligand binding study using membrane fractions isolated from CHO cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2009
Entry Details Article
PubMed
TargetVasopressin V1a receptor(Human)
Astellas Pharma

LigandPNGBDBM35673(BMC169524 Compound 10a | 5H-1-benzazepin-5-ylidene...)
Affinity DataKi:  26nM ΔG°:  -10.3kcal/moleT: 2°CAssay Description:The affinities of test compounds for human V2 receptor were evaluated by the radioligand binding study using membrane fractions isolated from CHO cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2009
Entry Details Article
PubMed