BDBM35678 5H-1-benzazepin-5-ylidene acetamide, 1f

SMILES COc1cccc(CNC(=O)\C=C2\c3ccccc3N(CCC2(F)F)C(=O)c2ccc(cc2Cl)-n2ccc(C)n2)n1

InChI Key InChIKey=VFGUUFALPPOHKD-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 35678   

TargetVasopressin V2 receptor(Human)
Astellas Pharma

LigandPNGBDBM35678(5H-1-benzazepin-5-ylidene acetamide, 1f)
Affinity DataKi:  16nM ΔG°:  -10.6kcal/molepH: 7.4 T: 2°CAssay Description:The affinities of test compounds for human V2 receptor were evaluated by the radioligand binding study using membrane fractions isolated from CHO cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2009
Entry Details Article
PubMed
TargetVasopressin V1a receptor(Human)
Astellas Pharma

LigandPNGBDBM35678(5H-1-benzazepin-5-ylidene acetamide, 1f)
Affinity DataKi:  47nM ΔG°:  -9.99kcal/moleT: 2°CAssay Description:The affinities of test compounds for human V2 receptor were evaluated by the radioligand binding study using membrane fractions isolated from CHO cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2009
Entry Details Article
PubMed