BDBM357634 7-(naphthalen- 2-ylmethyl)- 3H-[1,2,3] triazolo[4,5- b]pyridin-5- amine::US10214527, Example 6

SMILES Nc1cc(Cc2ccc3ccccc3c2)c2nn[nH]c2n1

InChI Key InChIKey=VLCJWTGGMJFGGC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 357634   

TargetMyeloperoxidase(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM357634(US10214527, Example 6 | 7-(naphthalen- 2-ylmethyl)...)
Affinity DataIC50: 500nMAssay Description:MPO peroxidation activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Amplex Red (Invitrogen catalog # A12222) which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
Go to US Patent

TargetMyeloperoxidase(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM357634(US10214527, Example 6 | 7-(naphthalen- 2-ylmethyl)...)
Affinity DataIC50: 57nMAssay Description:Inhibition of recombinant human MPO incubated for 10 mins in presence of 240 mM NaCl and 10 uM H2O2 by aminophenyl fluorescein based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetMyeloperoxidase(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM357634(US10214527, Example 6 | 7-(naphthalen- 2-ylmethyl)...)
Affinity DataIC50: 188nMAssay Description:Inhibition of recombinant human MPO incubated for 10 mins by amplex red dye based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed