BDBM357729 US10214528, Example 33::US10738048, Example 33::US11014923, Example 33::US11667635, Example 33::US9890156, Example 33::methyl 4-((7-(acrylamidomethyl)-3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-3,4-dihydropyrido[4,3-d]pyrimidin-1(2H)-yl)methyl)piperidine-1-carboxylate

SMILES COC(=O)N1CCC(CN2C(=O)N(Cc3cnc(CNC(=O)C=C)cc23)c2c(F)c(OC)cc(OC)c2F)CC1

InChI Key InChIKey=GVEQIOVJIHWDCL-UHFFFAOYSA-N

Data  20 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 357729   

TargetFibroblast growth factor receptor 3(Human)
Incyte

US Patent

LigandBDBM357729(methyl 4-((7-(acrylamidomethyl)-3-(2,6-difluoro-3,...)Copy SMILESCopy InChI

Affinity DataIC50: 115nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
4/4/2021
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TargetFibroblast growth factor receptor 4(Human)
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US Patent

LigandBDBM357729(methyl 4-((7-(acrylamidomethyl)-3-(2,6-difluoro-3,...)Copy SMILESCopy InChI

Affinity DataIC50: 10nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
7/9/2023
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TargetFibroblast growth factor receptor 3(Human)
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US Patent

LigandBDBM357729(methyl 4-((7-(acrylamidomethyl)-3-(2,6-difluoro-3,...)Copy SMILESCopy InChI

Affinity DataIC50: 115nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
7/9/2023
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TargetFibroblast growth factor receptor 2(Human)
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US Patent

LigandBDBM357729(methyl 4-((7-(acrylamidomethyl)-3-(2,6-difluoro-3,...)Copy SMILESCopy InChI

Affinity DataIC50: 200nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
7/9/2023
Entry Details
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TargetFibroblast growth factor receptor 1(Human)
Incyte

US Patent

LigandBDBM357729(methyl 4-((7-(acrylamidomethyl)-3-(2,6-difluoro-3,...)Copy SMILESCopy InChI

Affinity DataIC50: 200nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
7/9/2023
Entry Details
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TargetFibroblast growth factor receptor 4(Human)
Incyte

US Patent

LigandBDBM357729(methyl 4-((7-(acrylamidomethyl)-3-(2,6-difluoro-3,...)Copy SMILESCopy InChI

Affinity DataIC50: 10nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
11/22/2021
Entry Details
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TargetFibroblast growth factor receptor 3(Human)
Incyte

US Patent

LigandBDBM357729(methyl 4-((7-(acrylamidomethyl)-3-(2,6-difluoro-3,...)Copy SMILESCopy InChI

Affinity DataIC50: 115nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
11/22/2021
Entry Details
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TargetFibroblast growth factor receptor 2(Human)
Incyte

US Patent

LigandBDBM357729(methyl 4-((7-(acrylamidomethyl)-3-(2,6-difluoro-3,...)Copy SMILESCopy InChI

Affinity DataIC50: 200nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
11/22/2021
Entry Details
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TargetFibroblast growth factor receptor 1(Human)
Incyte

US Patent

LigandBDBM357729(methyl 4-((7-(acrylamidomethyl)-3-(2,6-difluoro-3,...)Copy SMILESCopy InChI

Affinity DataIC50: 200nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
11/22/2021
Entry Details
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TargetFibroblast growth factor receptor 4(Human)
Incyte

US Patent

LigandBDBM357729(methyl 4-((7-(acrylamidomethyl)-3-(2,6-difluoro-3,...)Copy SMILESCopy InChI

Affinity DataIC50: 10nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
4/4/2021
Entry Details
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TargetFibroblast growth factor receptor 1(Human)
Incyte

US Patent

LigandBDBM357729(methyl 4-((7-(acrylamidomethyl)-3-(2,6-difluoro-3,...)Copy SMILESCopy InChI

Affinity DataIC50: 200nMAssay Description:TBDMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/20/2019
Entry Details
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TargetFibroblast growth factor receptor 2(Human)
Incyte

US Patent

LigandBDBM357729(methyl 4-((7-(acrylamidomethyl)-3-(2,6-difluoro-3,...)Copy SMILESCopy InChI

Affinity DataIC50: 200nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
4/4/2021
Entry Details
Copy Entry DOIGo to US Patent

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TargetFibroblast growth factor receptor 1(Human)
Incyte

US Patent

LigandBDBM357729(methyl 4-((7-(acrylamidomethyl)-3-(2,6-difluoro-3,...)Copy SMILESCopy InChI

Affinity DataIC50: 200nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
4/4/2021
Entry Details
Copy Entry DOIGo to US Patent

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TargetFibroblast growth factor receptor 4(Human)
Incyte

US Patent

LigandBDBM357729(methyl 4-((7-(acrylamidomethyl)-3-(2,6-difluoro-3,...)Copy SMILESCopy InChI

Affinity DataIC50: 10nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/16/2020
Entry Details
Copy Entry DOIGo to US Patent

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TargetFibroblast growth factor receptor 3(Human)
Incyte

US Patent

LigandBDBM357729(methyl 4-((7-(acrylamidomethyl)-3-(2,6-difluoro-3,...)Copy SMILESCopy InChI

Affinity DataIC50: 125nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/16/2020
Entry Details
Copy Entry DOIGo to US Patent

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TargetFibroblast growth factor receptor 2(Human)
Incyte

US Patent

LigandBDBM357729(methyl 4-((7-(acrylamidomethyl)-3-(2,6-difluoro-3,...)Copy SMILESCopy InChI

Affinity DataIC50: 200nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/16/2020
Entry Details
Copy Entry DOIGo to US Patent

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TargetFibroblast growth factor receptor 1(Human)
Incyte

US Patent

LigandBDBM357729(methyl 4-((7-(acrylamidomethyl)-3-(2,6-difluoro-3,...)Copy SMILESCopy InChI

Affinity DataIC50: 200nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/16/2020
Entry Details
Copy Entry DOIGo to US Patent

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TargetFibroblast growth factor receptor 4(Human)
Incyte

US Patent

LigandBDBM357729(methyl 4-((7-(acrylamidomethyl)-3-(2,6-difluoro-3,...)Copy SMILESCopy InChI

Affinity DataIC50: 10nMAssay Description:TBDMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/20/2019
Entry Details
Copy Entry DOIGo to US Patent

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TargetFibroblast growth factor receptor 3(Human)
Incyte

US Patent

LigandBDBM357729(methyl 4-((7-(acrylamidomethyl)-3-(2,6-difluoro-3,...)Copy SMILESCopy InChI

Affinity DataIC50: 115nMAssay Description:TBDMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/20/2019
Entry Details
Copy Entry DOIGo to US Patent

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TargetFibroblast growth factor receptor 2(Human)
Incyte

US Patent

LigandBDBM357729(methyl 4-((7-(acrylamidomethyl)-3-(2,6-difluoro-3,...)Copy SMILESCopy InChI

Affinity DataIC50: 200nMAssay Description:TBDMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/20/2019
Entry Details
Copy Entry DOIGo to US Patent

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