BDBM357903 2-Amino-7-isopentyl-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid::US10214536, Compound 243a

SMILES CC(C)CCc1ccc2oc3nc(N)c(cc3c(=O)c2c1)C(O)=O

InChI Key InChIKey=PTJMIMUODVJDSY-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 357903   

TargetSerine/threonine-protein kinase TBK1(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM357903(US10214536, Compound 243a | 2-Amino-7-isopentyl-5-...)
Affinity DataIC50: 830nMAssay Description:Inhibition of human TBK1 (1 to 657 residues) expressed in Baculovirus infected SF9 insect cells using myelin basic protein as substrate in presence o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM357903(US10214536, Compound 243a | 2-Amino-7-isopentyl-5-...)
Affinity DataIC50: 830nMAssay Description:Inhibition of human TBK1 (1 to 657 residues) expressed in Baculovirus infected SF9 insect cells using myelin basic protein as substrate in presence o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM357903(US10214536, Compound 243a | 2-Amino-7-isopentyl-5-...)
Affinity DataIC50: 2.01E+3nMAssay Description:Kinase assays are commonly used for determining the ability of a small molecule to inhibit enzyme activity. By measuring the degree of phosphorylatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM357903(US10214536, Compound 243a | 2-Amino-7-isopentyl-5-...)
Affinity DataIC50: 3.39E+3nMAssay Description:Inhibition of human IKKepsilon (1 to 655 residues) expressed in Baculovirus infected SF9 insect cells using myelin basic protein as substrate in pres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM357903(US10214536, Compound 243a | 2-Amino-7-isopentyl-5-...)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of human IKKepsilon (1 to 655 residues) expressed in Baculovirus infected SF9 insect cells using myelin basic protein as substrate in pres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed