BDBM358363 4-acetyl-1-(5-{4-amino-5-[1-(propane- 2-sulfonyl)-1H-pyrazol-4-yl]pyrrolo [2,1-f][1,2,4]triazin-7-yl}-2- fluorophenyl)-3,3-dimethylpiperazin-2- one::US10214537, Example 433

SMILES CC(C)S(=O)(=O)n1cc(cn1)-c1cc(-c2ccc(F)c(c2)N2CCN(C(C)=O)C(C)(C)C2=O)n2ncnc(N)c12

InChI Key InChIKey=RSAPFVJNAKBWLT-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 358363   

LigandPNGBDBM358363(US10214537, Example 433 | 4-acetyl-1-(5-{4-amino-5...)
Affinity DataIC50: 0.400nMAssay Description:The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent