BDBM358657 (S)-4-(4-amino-5-(trifluoromethyl) pyrrolo[2,1-f][1,2,4]triazin-7-yl)-2-(5- ethyl-2,2-dimethyl-3-oxomorpholino) benzonitrile::US10214537, Example 734::US10214537, Example 735

SMILES CC[C@H]1COC(C)(C)C(=O)N1c1cc(ccc1C#N)-c1cc(c2c(N)ncnn12)C(F)(F)F

InChI Key InChIKey=GGLBMZQGKMGJKM-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 358657   

LigandPNGBDBM358657((S)-4-(4-amino-5-(trifluoromethyl) pyrrolo[2,1-f][...)
Affinity DataIC50: 0.400nMAssay Description:The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent

LigandPNGBDBM358657((S)-4-(4-amino-5-(trifluoromethyl) pyrrolo[2,1-f][...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of PI3Kdelta (unknown origin) after 60 mins using fluorescein-labeled kinase tracer by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2019
Entry Details Article
PubMed
LigandPNGBDBM358657((S)-4-(4-amino-5-(trifluoromethyl) pyrrolo[2,1-f][...)
Affinity DataIC50: 2nMAssay Description:The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent

LigandPNGBDBM358657((S)-4-(4-amino-5-(trifluoromethyl) pyrrolo[2,1-f][...)
Affinity DataIC50: 42nMAssay Description:Inhibition of PI3Kdelta in ACD-treated human whole blood assessed as reduction in CD69 expression measured after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2019
Entry Details Article
PubMed
LigandPNGBDBM358657((S)-4-(4-amino-5-(trifluoromethyl) pyrrolo[2,1-f][...)
Affinity DataIC50: 88nMAssay Description:Inhibition of PI3Kdelta in ACD-treated human whole blood assessed as reduction in IFNgammaX production measured after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2019
Entry Details Article
PubMed