BDBM358669 1-(3-(4-amino-5-chloropyrrolo[2,1-f] [1,2,4]triazin-7-yl)phenyl)-3,3- dimethyl-4-(2-(2-oxopyrrolidin-1- yl)acetyl)piperazin-2-one::US10214537, Example 746

SMILES CC1(C)N(CCN(C1=O)c1cccc(c1)-c1cc(Cl)c2c(N)ncnn12)C(=O)CN1CCCC1=O

InChI Key InChIKey=QIGMNZRIGQFPBY-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 358669   

LigandPNGBDBM358669(1-(3-(4-amino-5-chloropyrrolo[2,1-f] [1,2,4]triazi...)
Affinity DataIC50: 0.400nMAssay Description:The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...More data for this Ligand-Target Pair
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Date in BDB:
10/20/2019
Entry Details
US Patent