BDBM358854 N-[2-(dimethylamino)ethyl]-N-methyl-3-[4-(morpholin-4-yl)furo[3,2-c]pyridin-2-yl]imidazo[1,2-b]pyridazine-6-carboxamide::US10214545, Example 3

SMILES CN(C)CCN(C)C(=O)c1ccc2ncc(-c3cc4c(nccc4o3)N3CCOCC3)n2n1

InChI Key InChIKey=FOYUODPUQZERHM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 358854   

TargetIsoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a)(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM358854(N-[2-(dimethylamino)ethyl]-N-methyl-3-[4-(morpholi...)
Affinity DataIC50: 88nMAssay Description:MKNK1-inhibitory activity of compounds of the present invention was quantified employing the MKNK1 TR-FRET assay as described in the following paragr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
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TargetIsoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a)(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM358854(N-[2-(dimethylamino)ethyl]-N-methyl-3-[4-(morpholi...)
Affinity DataIC50: 140nMAssay Description:MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
Go to US Patent