BDBM358855 (4-Methylpiperazin-1-yl){3-[4-(morpholin-4-yl)furo[3,2-c]pyridin-2-yl]imidazo-[1,2-b]pyridazin-6-yl}methanone::US10214545, Example 4

SMILES CN1CCN(CC1)C(=O)c1ccc2ncc(-c3cc4c(nccc4o3)N3CCOCC3)n2n1

InChI Key InChIKey=GRIUCHRPBVVMKI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 358855   

TargetIsoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a)(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM358855((4-Methylpiperazin-1-yl){3-[4-(morpholin-4-yl)furo...)
Affinity DataIC50: 110nMAssay Description:MKNK1-inhibitory activity of compounds of the present invention was quantified employing the MKNK1 TR-FRET assay as described in the following paragr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent

TargetIsoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a)(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM358855((4-Methylpiperazin-1-yl){3-[4-(morpholin-4-yl)furo...)
Affinity DataIC50: 280nMAssay Description:MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent