BDBM361515 N-(2-((3,5- difluoro-4- ((1R,3R)-3- methyl-2- (2,2,2- trifluoroethyl)- 2,3,4,9- tetrahydro-1H- pyrido[3,4- b]indol-1- yl)pyridin-2- yl)oxy)ethyl)- 3- fluoropropan- 1-amine::US10221173, Example 107::US10590132, Example 107::US11046689, Example 107

SMILES C[C@@H]1Cc2c([nH]c3ccccc23)[C@H](N1CC(F)(F)F)c1c(F)cnc(OCCNCCCF)c1F

InChI Key InChIKey=FGJFWVZUSZMTOU-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 361515   

TargetEstrogen receptor(Human)
Astrazeneca

US Patent
LigandPNGBDBM361515(N-(2-((3,5- difluoro-4- ((1R,3R)-3- methyl-2- (2,2...)
Affinity DataIC50: 1.30nMAssay Description:The ability of compounds to bind to isolated Estrogen Receptor Alpha Ligand binding domain (ER alpha LBD (GST)) was assessed in competition assays us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Astrazeneca

US Patent
LigandPNGBDBM361515(N-(2-((3,5- difluoro-4- ((1R,3R)-3- methyl-2- (2,2...)
Affinity DataIC50: 0.210nMAssay Description:The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
Go to US Patent

LigandPNGBDBM361515(N-(2-((3,5- difluoro-4- ((1R,3R)-3- methyl-2- (2,2...)
Affinity DataIC50: 8.10E+3nMAssay Description:hERG (human ether a go go-related gene) potassium channels are essential for normal electrical activity in the heart. Arrhythmia can be induced by a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
Go to US Patent

TargetEstrogen receptor [307-554](Human)
Astrazeneca

US Patent
LigandPNGBDBM361515(N-(2-((3,5- difluoro-4- ((1R,3R)-3- methyl-2- (2,2...)
Affinity DataIC50: 1.30nMAssay Description:ERα: The ability of compounds to bind to isolated Estrogen Receptor Alpha Ligand binding domain (ER alpha-LBD (GST)) was assessed in competition...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent

LigandPNGBDBM361515(N-(2-((3,5- difluoro-4- ((1R,3R)-3- methyl-2- (2,2...)
Affinity DataIC50: 8.10E+3nMAssay Description:hERG: The purpose of the hERG binding assay is to evaluate the effects of test compounds on the voltage-dependent potassium channel encoded by the hu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Astrazeneca

US Patent
LigandPNGBDBM361515(N-(2-((3,5- difluoro-4- ((1R,3R)-3- methyl-2- (2,2...)
Affinity DataIC50: 1.30nMAssay Description:The ability of compounds to bind to isolated Estrogen Receptor Alpha Ligand binding domain (ER alpha-LBD (GST)) was assessed in competition assays us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
Go to US Patent

LigandPNGBDBM361515(N-(2-((3,5- difluoro-4- ((1R,3R)-3- methyl-2- (2,2...)
Affinity DataIC50: 8.10E+3nMAssay Description:hERG (human ether a go go-related gene) potassium channels are essential for normal electrical activity in the heart. Arrhythmia can be induced by a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
Go to US Patent