BDBM362162 1-(3-(5-chloro-4-oxo-2-(1-(thiazolo[5,4-d]pyrimidin-7-yloxy)ethyl)quinazolin-3(4H)-yl)phenyl)-3-(2-chlorophenyl)urea::US10221197, Compound 156

SMILES C[C@H](Oc1ncnc2scnc12)c1nc2cccc(Cl)c2c(=O)n1-c1cccc(NC(=O)NCC2OCCO2)c1

InChI Key InChIKey=WASWABXRHJZKFE-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 362162   

LigandPNGBDBM362162(1-(3-(5-chloro-4-oxo-2-(1-(thiazolo[5,4-d]pyrimidi...)
Affinity DataIC50: 2.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
US Patent

LigandPNGBDBM362162(1-(3-(5-chloro-4-oxo-2-(1-(thiazolo[5,4-d]pyrimidi...)
Affinity DataIC50: 2.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
US Patent

TargetPhosphatidylinositol 3-kinase regulatory subunit beta(Human)
Gilead Sciences

US Patent
LigandPNGBDBM362162(1-(3-(5-chloro-4-oxo-2-(1-(thiazolo[5,4-d]pyrimidi...)
Affinity DataIC50: 4.10E+4nMAssay Description:TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIP3 for binding to the GRP-1 plecks...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
US Patent

TargetPhosphatidylinositol 3-kinase regulatory subunit beta(Human)
Gilead Sciences

US Patent
LigandPNGBDBM362162(1-(3-(5-chloro-4-oxo-2-(1-(thiazolo[5,4-d]pyrimidi...)
Affinity DataIC50: 4.10E+4nMAssay Description:TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIP3 for binding to the GRP-1 plecks...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
US Patent

LigandPNGBDBM362162(1-(3-(5-chloro-4-oxo-2-(1-(thiazolo[5,4-d]pyrimidi...)
Affinity DataIC50: 9.30E+5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
US Patent

LigandPNGBDBM362162(1-(3-(5-chloro-4-oxo-2-(1-(thiazolo[5,4-d]pyrimidi...)
Affinity DataIC50: 9.30E+5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
US Patent