BDBM364449 (R or S)-N-[5-(1-hydroxyethyl)-2- phenyl-2H-indazol-3-yl]-3-(1- methyl-1H-pyrazol-3-yl)-4- (trifluoromethyl)benzamide, isomer A::US9862707, Example 23::US9862707, Example 24

SMILES CC(O)c1ccc2nn(c(NC(=O)c3ccc(c(c3)-c3ccn(C)n3)C(F)(F)F)c2c1)-c1ccccc1

InChI Key InChIKey=MDANURKSLYFPRZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 364449   

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM364449(US9862707, Example 23 | (R or S)-N-[5-(1-hydroxyet...)
Affinity DataIC50: 2.40nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM364449(US9862707, Example 23 | (R or S)-N-[5-(1-hydroxyet...)
Affinity DataIC50: 3.70nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent