BDBM364463 (R or S)-2-chloro-N-[6-(1- hydroxyethyl)-2-phenyl-2H- indazol-3 -yl]-5-pyrimidin-2-yl-4- (trifluoromethyl)benzamide, isomer A::US9862707, Example 37::US9862707, Example 38

SMILES CC(O)c1ccc2c(NC(=O)c3cc(-c4ncccn4)c(cc3Cl)C(F)(F)F)n(nc2c1)-c1ccccc1

InChI Key InChIKey=LLVGDVKKDXMYDS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 364463   

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM364463(US9862707, Example 37 | US9862707, Example 38 | (R...)
Affinity DataIC50: 4.40nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM364463(US9862707, Example 37 | US9862707, Example 38 | (R...)
Affinity DataIC50: 4.90nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent