BDBM364472 2-chloro-N-[6-(1-hydroxy-1- methylethyl)-2-phenyl-2H-indazol- 3-yl]-5-pyrimidin-2-yl-4- (trifluoromethyl)benzamide::US9862707, Example 46

SMILES CC(C)(O)c1ccc2c(NC(=O)c3cc(-c4ncccn4)c(cc3Cl)C(F)(F)F)n(nc2c1)-c1ccccc1

InChI Key InChIKey=LNPFNUJPXPEIBG-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 364472   

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM364472(US9862707, Example 46 | 2-chloro-N-[6-(1-hydroxy-1...)
Affinity DataIC50: 1.70nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent