BDBM364480 (R or S)-2-fluoro-N-(2-phenyl-5- (2,2,2-trifluoro-1-hydroxyethyl)- 2H-indazol-3-yl)-5-(pyrimidin-2- yl)-4-(trifluoromethyl)benzamide, isomer A::US9862707, Example 54::US9862707, Example 55

SMILES OC(c1ccc2nn(c(NC(=O)c3cc(-c4ncccn4)c(cc3F)C(F)(F)F)c2c1)-c1ccccc1)C(F)(F)F

InChI Key InChIKey=YNMXTDHKBPXWFH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 364480   

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM364480(US9862707, Example 54 | US9862707, Example 55 | (R...)
Affinity DataIC50: 0.820nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM364480(US9862707, Example 54 | US9862707, Example 55 | (R...)
Affinity DataIC50: 23nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent