BDBM364482 (R or S)-N-[6-(2,2-difluoro-1- hydroxyethyl)-2-phenyl-2H- indazol-3-yl]-2-fluoro-5-pyrimidin- 2-yl-4-(trifluoromethyl)benzamide, isomer A::US9862707, Example 56::US9862707, Example 57

SMILES OC(C(F)F)c1ccc2c(NC(=O)c3cc(-c4ncccn4)c(cc3F)C(F)(F)F)n(nc2c1)-c1ccccc1

InChI Key InChIKey=KGAQXHWMFVCAJX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 364482   

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM364482(US9862707, Example 56 | US9862707, Example 57 | (R...)
Affinity DataIC50: 2.80nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM364482(US9862707, Example 56 | US9862707, Example 57 | (R...)
Affinity DataIC50: 13nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent